Product Description
The effect on gram-positive bacteria is similar to that of ampicillin. It has a good antibacterial effect on enterococcus and some bacteroides and Clostridium. Against gram-negative bacteria, including Neisseria gonorrhoeae, Escherichia coli, proteus, Klebsiella pneumoniae, Pseudomonas aeruginosa, citrobacter, Enterobacteriaceae, Haemophilus influenzae, etc. , although it has antibacterial effect on salmonella, Shigella, Pseudomonas, Neisseria meningitidis, and Yersinia in vitro, its clinical significance is not clear yet. The product is not absorbed by mouth. The serum drug concentration peaked at 1/2 hour after intramuscular injection of 2 g, about 36 μg/ml. 4G was given intravenously within 30 minutes, and the immediate blood concentration was 200 μg/ml, ≥100 μg/ml at 1 hour, and T 1/2 was about 1 hour. It is widely distributed in the body and can reach the effective concentration in the surrounding organs. This product mainly excretes by the kidney, in 12 hours the urine may excrete gives the medicine quantity 1/2 ~ 2/3. It is clinically used for the infection caused by the above-mentioned sensitive strains (the curative effect on central infection is not exact) .
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