| Application: | Internal Medicine |
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| Usage Mode: | For external use |
| Suitable for: | Elderly, Children, Adult |
| State: | Solid |
| Shape: | Oral Liquid |
| Type: | Organic Chemicals |
| Samples: |
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| Customization: |
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Audited Supplier | Product name | Cefoperazone Sodium and Sulbactam Sodium for Injection |
| Specificaton | 1.0g/1.5g/2.0g |
| Certification | GMP ISO9001 ISO14001 |
| Standard | USP |
| Function | This product is used to treat the following infections caused by sensitive bacteria: Respiratory infections (upper and lower respiratory); Urinary tract infection (upper and lower urinary tract); Peritonitis, cholecystitis, cholangitis and other intra-abdominal infections; Septicemia, meningitis; Skin and soft tissue infections, eye infections, bone and joint infections; Pelvic inflammatory disease, endometritis, gonorrhea and other genital, tract infections; Prevent postoperative infection caused by abdominal cavity, gynecology, cardiovascular, orthopedics and plastic surgery. |
| announcements | 1. Before the application of cefoperazone-sulbactam, the patient must be asked in detail whether there is a previous history of allergy to this product, other cephalosporins, penicillins or other drugs, because there are beta lactams such as penicillins and cephalosporins There may be cross-allergic reactions between antibiotics. About 5% to 10% of patients allergic to penicillin antibiotics may have cross-allergic reactions to cephalosporins. Therefore, patients with a history of penicillin allergy should use this product with caution under close observation after fully weighing the pros and cons when indicated. When using this product, once an allergic reaction occurs, the drug should be stopped immediately. In the event of anaphylactic shock, immediate rescue on the spot is required, and emergency measures such as adrenaline, keeping the airway open, oxygen inhalation, corticosteroids, and antihistamines. 2. This product should not be directly dissolved in calcium-containing injections such as Ringer's solution, otherwise it will produce milky white precipitate; it cannot be dissolved in acidic liquids, because cefoperazone acid may precipitate when the pH is lower than 4.5. 3. This product is formulated with various suitable diluents. It should be used within 24 hours in a dark and cool place. If it is stored for more than this time, it should be discarded and not used. 4. Most of cefoperazone is excreted through the hepatobiliary system, so patients with severely impaired liver function need to adjust the dosage regimen when using this product. 5. If this product is opaque after dissolving, it is caused by the low pH of the diluent. Never heat it to aid dissolution to avoid damage to the drug. The diluent can be appropriately added to dissolve, or a small amount of sodium bicarbonate injection can be dissolved and transparent. 6. Patients with severely impaired renal function need to adjust the dosage and administration interval when using cefoperazone-sulbactam. 7. The half-life of cefoperazone-sulbactam sodium in the elderly with renal insufficiency and liver dysfunction is prolonged, drug clearance is reduced, and volume of distribution increases. The pharmacokinetic parameters of cefoperazone are closely related to the degree of liver damage, while the pharmacokinetic parameters of sulbactam are closely related to the degree of renal damage. Therefore, patients with renal insufficiency and/or liver function need to adjust the dose. 8. A small number of patients develop vitamin K deficiency after treatment with cefoperazone-sulbactam. The mechanism is probably related to the inhibition of intestinal flora. Patients with malnutrition, malabsorption (such as patients with cystic fibrosis), long-term intravenous injection of high-nutrient preparations and patients receiving anticoagulant therapy should supplement vitamin K when using this product, and monitor the prothrombin time. 9. It has been reported that patients who drink alcohol during and within 5 days after taking cefoperazone can cause facial flushing, sweating, headaches and tachycardia. Patients should avoid drinking alcoholic beverages when using this product. Also avoid parenteral administration of high-nutrient preparations containing alcohol. 10. Both cefoperazone and sulbactam can cause direct Coombs test positive. 11. The combined application of this product and aminoglycoside drugs has a synergistic effect. 12. When cefoperazone-sulbactam is used, a false-positive reaction may appear when checking urine glucose with Benidict solution or Fehling reagent. 13. The packaging of waste medicines should not be discarded randomly. |
| usage and dosage | Intramuscular or intravenous injection. The daily dosage for adults is 1~2g based on the amount of cefoperazone, divided into equal amounts, and injected once every 12 hours. For severe or refractory infections, the daily dose can be increased to 8g, divided into equal amounts, and injected once every 12 hours. However, the total amount of sulbactam should not exceed 4g per day. Severe renal insufficiency, due to the reduced clearance of sulbactam, the dosage regimen should be adjusted appropriately. For patients whose creatinine clearance rate is between 16-30ml/min, the maximum dosage of this product should not exceed 1g per 12 hours; if the creatinine clearance rate is less than 15ml/min, the product contains sulbactam every 12 hours. It should not exceed 0.5g. Intramuscular injection: This product is directly dissolved in 4ml (3ml for 0.75g specification) sterilized water for injection per 1.5g, and then injected into deep muscles. If lidocaine needs to be added, it should be added after dissolving in sterile water for injection. Lidocaine injection should not be used directly to dissolve this product, otherwise turbidity or precipitation will occur. Intravenous injection: First dissolve this product in 0.75g, 1.5g specifications with 5ml or 2.25g, 3.0g specifications with 10ml sterile water for injection or 0.9% sodium chloride injection, and then add this solution to a suitable infusion for intravenous injection or Drip. Commonly used infusions that can be used to dilute this product are: 0.9% sodium chloride injection, 5% glucose injection, glucose sodium chloride injection, and 10% glucose injection. If it is diluted with Ringer's solution, the product must be dissolved with sterile water for injection and then slowly added to Ringer's solution, otherwise it will produce milky white precipitate. |
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