Cefuroxime for Injection
This product is the second generation cephalosporin antibiotics. Its mechanism of action is to inhibit the synthesis of bacterial cell wall by binding bacterial protein. Cefuroxime has a wide range of antibacterial activity against pathogens, and is stable to many β - lactamases, especially to plasmid mediated enzymes commonly found in Enterobacteriaceae.
Cefuroxime has antibacterial activity against most of the following bacteria in vitro and in clinical infection treatment
Aerobic gram positive bacteria: Staphylococcus aureus (including β - lactamase producing bacteria), Streptococcus pneumoniae and Streptococcus pyogenes.
Aerobic gram negative bacteria: Escherichia coli, influenza bacillus (including β - lactamase producing bacteria), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including β - lactamase producing bacteria), Neisseria gonorrhoeae (including β - lactamase producing bacteria).
In vitro tests showed that most of Enterococcus faecalis, methicillin-resistant Staphylococcus aureus, Clostridium difficile and Bacteroides fragilis were resistant to cefuroxime.
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