Streptomycin Sulfate for Injection
Streptomycin sulfate is an aminoglycoside antibiotic. Streptomycin has strong antibacterial effect on Mycobacterium tuberculosis, and its minimum inhibitory concentration is generally 0.5 μ g / ml. Most of nontuberculous mycobacteria were resistant to this drug. Streptomycin also has antibacterial effect on many gram-negative bacilli, such as Escherichia coli, Klebsiella, proteus, enterobacter, Salmonella, Shigella, Brucella, Pasteurella, etc.; Neisseria meningitidis and Neisseria gonorrhoeae are also sensitive to this product. Streptomycin had poor effect on Staphylococcus and other gram positive cocci. Streptococcus, Pseudomonas aeruginosa and anaerobic bacteria were resistant to the drug.
Streptomycin mainly binds to bacterial ribosomal 30S subunit and inhibits bacterial protein synthesis. It is easy for bacteria to develop drug resistance after contacting with streptomycin. The combination of streptomycin and other antibiotics or anti tuberculosis drugs can reduce or delay the development of drug resistance.
Streptomycin sulfate for injection, indications for 1. This product is mainly used in combination with other anti tuberculosis drugs in the initial treatment of tuberculosis caused by Mycobacterium tuberculosis, or other sensitive Mycobacterium infection. 2. This product can be used for the treatment of tularemia alone, or combined with other antibiotics for the treatment of plague, inguinal granuloma, brucellosis, rat bite fever, etc. 3. It can also be combined with penicillin or ampicillin to treat endocarditis caused by Streptococcus viridis or Enterococcus.
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