Reduced Glutathione for Injection
Reduced glutathione for injection is used to prevent and treat tissue and cell damage caused by drugs [such as chemotherapy drugs, antituberculosis drugs, psychoneurology drugs, paracetamol, etc.), radiotherapy, alcohol and organophosphorus, etc.; it has protective effect on liver injury caused by various reasons.
It is also found in many kinds of cytoplasmic substances, such as glutathione, glutathione and glutathione. The sulfhydryl group of cysteine in reduced glutathione is highly nucleophilic, so it is the main target structure of electrophiles excited by xenobiotics or their metabolites, thus protecting the main nucleophilic sites. If the latter is affected, it will lead to cell damage. Once it reacts with organic oxidative metabolites, it can form low toxicity compounds which are easy to metabolize. The level of intracellular glutathione changes and the concentration decreases in many cases such as malnutrition, various diseases, chemical poisoning and drug administration. In animals and humans, reduced glutathione has protective effects on cytotoxicity induced by many substances such as salicylic acid, organophosphorus insecticides and alcohol. In vivo studies have shown that reduced glutathione does not affect intestinal dynamics, blood pressure and respiration, and does not cause ECG changes.
Toxicological study
Acute toxicity test: intravenous infusion of glutathione sodium salt at the dose of 1000mg / kg will not cause death of rats and mice. Rabbits could tolerate the dose of 3000mg / kg. Intraperitoneal administration of 7500mg / kg did not cause death in rats and mice.
Repeated dose toxicity test: glutathione sodium salt was infused intravenously at the daily doses of 500mg / kg / D and 1000mg / kg / D for 28 consecutive days without any pathological changes in rabbits. Glutathione sodium salt was administered intraperitoneally at the doses of 4386 mg / kg / day and 129 mg / kg / day for 90 consecutive days without any pathological symptoms or abnormal histological and biochemical parameters.
Teratogenicity test: glutathione salt was given to Wistar mice and New Zealand rabbits at the dose of 86 mg / kg / day, which did not affect the reproduction, growth and lactation of newborn animals.
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