GMP Ciprofloxacin Film-Coated Tablets with Good Price

• Application: Internal Medicine
• Usage Mode: For oral administration
• Suitable for: Elderly, Children, Adult
• State: Solid
• Shape: Tablet
• Type: Organic Chemicals
• Model NO.: 180527
• Pharmaceutical Technology: Chemical Synthesis
• Transport Package: 10tablet/Blister, 100/1000tablet/Tin
• Specification: 500mg
• Trademark: REYOUNG
• Origin: China

Product Description

product name:	Ciprofloxacin Film-coated Tablets
specification:	500 mg
shelf life:	36 months
certification:	GMP,ISO9001,ISO14001
standard:	USP

The main ingredient of this product is ciprofloxacin hydrochloride. Its chemical name is 1-propyl-fluoro-1,4-dihydro-4-oxo-7 (1-piperazine) -3-quinoline carboxylate-hydrate.
Molecular formula:385.82

Character:

This product is white or white-like or film-coated. After removing the coating, it appears white or white-like.

Pharmacology and Toxicology:

This product has broad-spectrum antimicrobial activity, especially against Gram-negative aerobic bacteria. It has good antimicrobial activity in vitro to most of the bacteria of Enterobacteriaceae, including Citrobacter, Cloacae, Aerobic Enterobacter, Escherichia coli, Klebsiella, Proteus, Salmonella. Bacteria, Shigella, Vibrio, Yersinia, etc. It also has antimicrobial activity against multidrug-resistant bacteria. Penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Moraxella have high antimicrobial activity. It has antimicrobial activity against most strains of Pseudomonas such as Pseudomonas aeruginosa. This product has antimicrobial activity against methicillin-sensitive staphylococcus, but only moderate antimicrobial activity against Streptococcus pneumoniae, Streptococcus hemolyticus and Enterococcus faecalis. It also has good effects on Chlamydia trachomatis, Mycoplasma, Legionella, Mycobacterium tuberculosis and atypical mycobacterium. The antimicrobial activity against anaerobic bacteria is poor.

Ciprofloxacin is a fungicide that inhibits the synthesis and replication of DNA by acting on the A subunit of bacterial DNA helicase.

Pharmacokinetics:

After taking 0.2g or 0.5g of this product, the peak concentration (Cmax) was 1.21 ug/ml and 2.5 ug/ml respectively, and the peak time (Tmax) was 1-2 hours. It is widely distributed in various tissues and body fluids (including cerebrospinal fluid). The concentration in tissues often exceeds that in blood. The protein binding rate is about 20% - 40%. Blood elimination half-life (T1/2beta) was 4 hours. It can be partially metabolized in the liver, and the metabolites still have weak activity. 24 hours after oral administration, 40% - 50% of the dose was excreted through the kidney in its original form. About 15% were excluded in the form of metabolites. At the same time, some drugs are excreted through bile and feces.

Indications:

Genitourinary tract infections, including simple, complex urinary tract infections, bacterial prostatitis, Neisseria gonorrhoeae urethritis or cervicitis (including those caused by enzyme-producing strains). A kind of
Respiratory tract infections, including acute outbreaks of bronchial infections caused by sensitive gram-negative bacilli and pulmonary infections. A kind of
Gastrointestinal tract infection is caused by Shigella, Salmonella, enterotoxin-producing Escherichia coli, Aeromonas hydrophila and Vibrio parahaemolyticus. Typhoid fever. A kind of
Bone and joint infections.